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National Repository of Grey Literature

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	Influence of antibacterial enzymes on preparation and properties of phosphate cements Přečková, Barbora ; Michlovská, Lenka (referee) ; Vojtová, Lucy (advisor) Předmětem této bakalářské práce je příprava kostního cementu z fosforečnanu vápenatého modifikovaného antibakteriálním enzymem pro účinnou a bezpečnou léčbu zánětu kosti (osteomyelitidy) v porovnání s léčbou antibiotiky. Teoretická část této bakalářské práce poskytuje informace o struktuře kostí, osteomyelitidě a léčbě osteomyelitidy různými typy antibakteriálních kostních cementů, především cementy na bázi fosforečnanu vápenatého. Experimentální část se zabývá optimalizací při přípravě vzorků, popisem použitých metod a charakteristikou kinetiky uvolňování enzymu z vytvrzeného cementu. Pro lepší pochopení mechanismu uvolňování enzymu z cementu byly připraveny a vyhodnoceny i modelové vzorky fosfátového cementu s enzymy i proteiny. Antibakteriální vlastnosti vzorků byly testovány použitím diskové, diluční a plotnové metody, což vedlo k výsledkům pozitivního inhibičního účinku antibakteriálního enzymu na grampozitivní bakterie (G+) kmenů Staphylococcus aureus a methicillin-rezistentní Staphylococcus aureus (MRSA), ale zanedbatelnému účinku na gramnegativní bakterii (G-) Escherichia coli. V následující práci bude zhodnocena in vitro biologická kompabilita cementů obsahující enzym. Detailed record
	Využití antimikrobiálních peptidů k léčbě infekcí pohybového ústrojí za pomoci lokálních nosičů užívaných v ortopedii Jahoda, David ; Melicherčík, Pavel ; Fakultní nemocnice v Motole (Praha, Česko) Detailed record
	Radikální chirurgické řešení víceetážových stenos u cervikální spondylogenní myelopatie kombinovaným přístupem Štětkářová, Ivana ; Prokop, Luděk ; Nemocnice Na Homolce. Detailed record
	Zdokonalení diagnostiky a možnosti celkové a lokální terapie chronické osteomyelitidy Karpaš, Karel ; Fakultní nemocnice (Hradec Králové, Česko) Detailed record

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